The TLR3 Agonist Inhibit Drug Efflux and Sequentially Consolidates Low-Dose Cisplatin-Based Chemoimmunotherapy while Reducing Side Effects

The TLR3 Agonist Inhibit Drug Efflux and Sequentially Consolidates Low-Dose Cisplatin-Based Chemoimmunotherapy while Reducing Side Effects.

The traditional maximum dose density chemotherapy renders the tumor patients not only the tumor remission but the chemotherapy resistance and more adverse side effects. According to the widely positive expression of Toll-like receptor (TLR)-3 in oral squamous cell carcinoma (OSCC) patients (n = 166), we here provided an alternative strategy involved the orderly treatment of TLR3 agonist polyino...

EVALUATION OF SIDE EFFECTS OF LOW DOSE CONTRACEPTIV E PILLS ADMINISTERED BY THE VAGINAL ROUTE

Oral contraceptive pills have several side effects especially on the gastrointestinal tract and liver. Absorption of low dose (LD) pills by the vaginal route avoids the first pass of the steroids through these tracts and probably has fewer side effects. This study was a cohort study for evaluation of side effects and acceptability of LD pills administered by the vaginal route. In a clinical...

Low dose naltrexone: side effects and efficacy in gastrointestinal disorders.

Use of low dose naltrexone has been advocated for a variety of medical problems. Only a few articles published in peer review journals have documented side effects of low dose naltrexone. The purpose of this study was to determine the frequency of adverse effects of low dose naltrexone in patients who have been treated for a variety of gastrointestinal disorders. The secondary purpose was to de...

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity, e.g., by interference with transcription and/or DNA replication mechanisms. Additionally, cisplatin damages tumors via induction of apoptosis, mediated by the activation of various signal transduction pathways, includi...

selenium can reduce the side effects of cisplatin as a chemotherapy drug